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Table 2 Extraction yield and anti-plasmodial activity of pure compounds isolated from H. lanceolatum

From: Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

Compound (code)

Quantity (mg)

Extraction yield

IC50 on W2mef (μM)

IC50 on SHF4 (μM)

HLT0

8

0.07

4.26 ± 0.15*

5.89 ± 0.20*

Betulinic acid (HLT1)

90

2.0

4.50 ± 1.35

5.60 ± 0.13

2,2',5,6'-Tetrahydroxybenzophenone (HLT2)

150

3.33

55.12 ± 0.93

13.41 ± 0.16

5-Hydroxy-3-methoxyxanthone (HLT3)

9

0.06

3.26 ± 0.08

1.43 ± 0.48

3-Hydroxy-5-methoxyxanthone (HLT4)

30

0.11

33.84 ± 0.20

34.09 ± 0.12

QN

-

-

0.27 ± 0.04

0.14 ± 0.05

  1. *IC50 expressed in μg/mL; Extraction yield expressed in % weight/weight of the ethylacetate fraction