Measuring naturally acquired immune responses to candidate malaria vaccine antigens in Ghanaian adults

Malaria Journal

Table 5 Individual urban and rural volunteers' ELISpot activity with HLA A or HLA B-matched short Class I-restricted peptides

		CSP		SSP2/TRAP		LSA1	LSA3
Site	Vol.	D4, D5	D6	D12-D14	D15	D29	D31-D35	D37
Urban	506	173				NT	180
	510			73		NT
Rural	1326		95		88		NT	NT
	1331							93
	1341	NT	NT	NT	NT	258		208

HLA-matches were defined for an HLA A or B allele. Two of 13 urban (506 and 510) and three of 17 rural (1326, 1331 and 1341) volunteers had positive ELISpot responses with HLA-matched short Class I-restricted peptides. Each number represents the mean of quadruplicate wells in a single assay with medium subtracted. No volunteer was infected with malaria. None of the twelve volunteers tested with EXP1 peptides were positive. NT = Not Tested:

ISSN: 1475-2875