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Table 2 Outcomes on day 28 by treatment group (odds ratios adjusted for age, weight, gender, and camp using logistic regression).

From: Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan

Outcomes

CQ 25 mg/kg

CQ 40 mg/kg

OR1 (95%CI)

Total enrolled

83

80

 

Total lost, excluded, or withdrawn

0

0

 

Mean days to fever clearance2 (95% CI)

2.6 (1.9, 3.3)

2.6 (1.9, 3.3)

 

Mean days to parasite clearance (95% CI)

2.9 (2.6, 3.1)

3.1 (2.8, 3.3)

 

Treatment outcomes: n = 163 (%)

   

Adequate clinical and parasitological response

13 (16)

40 (50)

1

Early treatment failure

6 (7)

6 (7)

0.28 (0.07, 1.09)

Late treatment failure***

64 (77)

34 (43)

0.16 (0.07, 0.35)

Parasitological outcomes: n = 163 (%)

   

S

13 (16)

39 (49)

 

RI

60 (72)

40 (50)

 

RII

10 (12)

1 (1)

 

First-line treatment success: n = 52 (%)

   

Complete parasitological cure without recrudescence***

13 (16)

39 (49)

0.17 (0.08, 0.38)

First-line treatment failures: n = 111 (%)

   

Age group

   

   0-5

17 (89)

11 (61)

0.18 (0.03, 1.05)

   6-14**

38 (86)

24 (55)

0.17 (0.06, 0.50)

   15+*

15 (75)

6 (33)

0.17 (0.04, 0.70)

Gender

   

   Male**

35 (81)

15 (47)

0.17 (0.06, 0.51)

   Female**

35 (88)

26 (54)

0.19 (0.07, 0.56)

Camp

   

   Adizai

17 (81)

11 (52)

0.26 (0.06, 1.12)

   Baghicha**

37 (84)

24 (51)

0.16 (0.06, 0.46)

   Kagan

16 (89)

6 (50)

0.23 (0.03, 1.63)

  1. NB: 1OR is odds ratio, comparing CQ40 to CQ25 adjusted for age, weight, gender, and refugee camp using logistic regression. 2FCT (< 37.5C) excludes those without fever on admission. *< 0.05,**p < 0.01,***p < 0.001