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Table 4 Parasitological outcomes among 81 treatment failures receiving second-line cq 40 mg/kg categorized by initial treatment group (odds ratios adjusted for age, weight, gender, and camp using logistic regression and 29 first-line failures from adizai excluded from analysis as these were treated with sp).

From: Clinical trial of extended-dose chloroquine for treatment of resistant falciparum malaria among Afghan refugees in Pakistan

Outcomes

CQ 25 mg/kg

CQ 40 mg/kg

Odds Ratio (95%CI)

Total receiving CQ40 second-line treatment

52

29

 

Lost, excluded

0

0

 

Treatment outcomes: n = 81 (%)

   

Adequate response

9 (17)

10 (34)

1

Early failure (0-3 days)

6 (12)

3 (10)

0.46 (0.09, 2.40)

Late failure (4-28 days)

37 (71)

16 (55)

0.41 (0.13, 1.20)

Second-line treatment success: n = 19 (%)

   

Complete parasitological cure (0-28 days)

9 (17)

10 (34)

0.41 (0.14, 1.19)

Second-line treatment failures: n = 62 (%)

   

Age group

   

   0-5

14 (93)

5 (62)

0.12 (0.01, 1.50)

   6-14

21 (84)

12 (75)

0.77 (0.14, 4.21)

   15+

8 (67)

2 (33)

0.27 (0.03, 2.45)

Gender

   

   Male

18 (82)

8 (67)

0.44 (0.09, 2.24)

   Female

25 (83)

11 (64)

0.37 (0.09, 1.46)

Camp

   

   Baghicha

29 (78)

15 (65)

0.52 (0.16, 1.66)

   Kagan

14 (93)

4 (67)

0.14 (0.01 2.05)