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Figure 1 | Malaria Journal

Figure 1

From: Design of a variant surface antigen-supplemented microarray chip for whole transcriptome analysis of multiple Plasmodium falciparum cytoadherent strains, and identification of strain-transcendent rif and stevor genes

Figure 1

Summary of the microarray chip design and experimental protocol. A bioinformatic approach was used to extract VSA sequences and design oligonucleotide probes for a particular strain, while the parasites were selected for and against a cytoadherence phenotype (rosetting). cDNA from positively and negatively selected parasites was hybridized on the "VSA-supplemented" 3D7-based microarray chip in order to identify cytoadherence gene candidates that were up-regulated in rosetting parasites compared to isogenic non-rosetting parasites.

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Malaria Journal

ISSN: 1475-2875

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