Parameters | Intravenous | Per-oral | ||
---|---|---|---|---|
 | 0.5 mg/kg | 10 mg/kg | 20 mg/kg | 40 mg/kg |
AUC 0-t (hr*ng/mL) | 9,189.76 ± 1,372.42 | 21,294.02 ± 3,235.75 | 17,683.7 ± 3,168.23 | 38,248.94 ± 7,792.61 |
AUC 0-∞ (hr*ng/mL) | 9,529.47 ± 1,283.18 | 22,025.48 ± 3,448.87 | 18,281.07 ± 3,062.84 | 39,958.71 ± 8,362.60 |
C max (ng/mL) | 1,890 ± 330.61 | 1,488 ± 311.47 | 938.75 ± 370.64 | 2,280 ± 522.32 |
T max (hr) | - | 8(2-8) | 3.5(2-8) | 5(2-8) |
Vd (L/kg) | 2.40 ± 0.67 | - | - | - |
CL (L/h/kg) | 0.03 ± 0.02 | - | - | - |
t 1/2 (hr) | 30.92 ± 4.81 | 36.08 ± 8.52 | 25.7 ± 1.85 | 38.23 ± 4.51 |
% F | - | 11.56 | 4.80 | 5.24 |