Skip to main content

Table 2 Analogues generated for determination of active sub-structures.

From: In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

Structure

D10 strain IC50

(μM)

n = 2

K1 strain

IC50

(μM)

n = 2

CHO IC50 (μM)

n = 2

1.865*

4.095#

17.2

11.5

9.05

7.01

> 40

NT

> 400

> 40

NT

> 400

22.1

NT

124

16.9

NT

41.9

  1. n = number of technical replicates averaged - each independent experiment performed in duplicate with several independent experiments performed for the parent compound dehydrobrachylaenolide
  2. * n = 8
  3. # n = 4