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Figure 5 | Malaria Journal

Figure 5

From: Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control

Figure 5

Effect of L-malate analogues on ME activity. A. Chemical structure of L-malate and structural analogues. B. Effect of L-malate analogues on ASE mitochondrial ME enzymatic activity. The activity of ME was evaluated in the absence and presence of the following inhibitors/compounds at saturating concentrations of all other cofactors and substrates except for succinate and fumarate which are shown at subsaturating concentrations of malate (0.5 mM): 1 mM oxaloacetate; 5 mM tartronic acid; 1 mM oxalate; 2.5 mM alpha-ketobutyrate; 2.5 mM beta-hydroxybutyrate; 2.5 mM alpha-hydroxybutyrate; 2.5 mM acetoacetate; 2.5 mM malonate; 10 mM pyruvate; 10 mM proline; 10 mM succinate; 10 mM glutamate; and 5 mM fumarate.

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