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Table 1 Recent trials of larvicides against malaria in Africa

From: Larval source management for malaria control in Africa: myths and reality

Study site

Ecosystem

Reduction in

Date of trial

  

Late instar Anopheles larval density

Anopheles gambiae s.l. adult density

Malaria infection

 

Semi-arid ecosystems, Eritrea [50]

Desert fringe

Significant reduction

Significant reduction

-

Not reported

Lake Victoria, Kenya [51]

Rural, high population density

99%

(97.5-99.4%)

91.5%

(91.4-91.6%)

-

Jul 2001-Sep 2005

Western Highlands, Kenya [52]

Rural, Highlands

91%

(87-95%)

86%

(80-88%)

56%

(18-77%)

Feb 2004-Jan 2007

Dar es Salaam, Tanzania [43, 53]

Urban

Not done1

34.5%

(19.1-46.7%)2

72%

(20-90%)

Apr 2005-May 2007

Middle reaches of the Gambia River, The Gambia [54]

Floodplains

73-99%3

No impact

No protection

Jul 2005-Nov 2007

  1. 1Larval density was not measured but proportion of habitats that contained late Anopheles larvae. There was a 96.5% reduction in Anopheles gambiae larval habitat abundance in year 1 as compared to the same time period pre-intervention and non-intervention sites [43]
  2. 2represents overall reduction in year 1 of intervention but late start during rainy season and operational challenges responsible for relative small reduction overall, the dry season larviciding in from July to September reduced transmission by 67% compared with the same time period pre-intervention and non-intervention sites
  3. 3Reduction in sites containing larvae compared with contemporary controls