Table 1 Immunization protocol
Immunogen VAR2CSA | Animal | Number of injections1 | Vaccination doses (μg) | ||
|---|---|---|---|---|---|
| Â | Â | Â | Â | Prime 2 | Boost 3 |
DBL1 | 7G8 | 3 rabbits 4 | 5 | 100 | 100 |
| Â | Â | 3 rats | 4 | 20 | 20 |
| Â | IT4 | 2 rabbits 5 | 6 | 500 | 250 |
DBL3 | 7G8 | 3 rats | 4 | 20 | 20 |
| Â | IT4 | 3 rabbits | 4 | 50 | 50 |
DBL4 short | IT4 | 3 rats | 4 | 20 | 20 |
| Â | Â | 2 rabbits 5 | 6 | 500 | 250 |
DBL4 long | 7G8 | 3 rats | 4 | 20 | 20 |
| Â | IT4 | 3 rats | 4 | 20 | 20 |
DBL4+DBL5 | 7G8 | 3 rats | 4 | 20+20 | 20+20 |
DBL5 | 7G8 | 3 rabbits 4 | 5 | 100 | 100 |
| Â | Â | 3 rats | 4 | 20 | 20 |
| Â | IT4 | 3 rabbits 4 | 5 | 25 | 25 |
| Â | 3D7 | 3 rabbits 4 | 5 | 50 | 50 |
| Â | Â | 3 rats | 4 | 20 | 20 |
DBL6 | 7G8 | 3 rats | 4 | 20 | 20 |
| Â | IT4 | 2 rabbits 5 | 6 | 500 | 250 |
| Â | Â | 3 rats | 4 | 20 | 20 |
Immunogen control var22 | Â | Â | Â | ||
DBL3 | IT4 | 3 rabbits 4 | 5 | 50 | 50 |
| Â | Â | 3 rats | 4 | 20 | 20 |