Figure 10
From: Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins
Schematic model of endothelial cell activation by kinin peptides generated by Plasmodium infected erythrocytes. iRBC possess permeability and transport pathways involved in plasma protein and peptide acquisition. Kinin peptides detected: bradykinin (BK), Des-Arg9-BK, Lys-BK; antagonists used for B1 (Des-Arg9[Leu8]-BK) and B2 (HOE-140) receptors; iRBC – infected erythrocytes; ER- endoplasmic reticulum; HK – human kininogen; EC – endothelial cell.