Figure 2
Correlations (r2 = 0.910-0.986) are shown between multiple intravenous doses and peak concentration (C max ) or area under the curve (AUC) with artesunate (AS) or dihydroartemisinin (DHA), an active metabolite from AS. A: mean samples (markers) were taken from Cmax of AS; B: mean values were taken from AUC of AS; C: mean samples were taken from Cmax of DHA; and D: mean values were taken from AUC of DHA in all three dose groups (2, 4, and 8 mg/kg) after AS treatments daily for three days. The line represents linear regression whose statistical parameters are shown in the inset (A-D).