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Figure 7 | Malaria Journal

Figure 7

From: Anti-plasmodial action of de novo-designed, cationic, lysine-branched, amphipathic, helical peptides

Figure 7

Kinetics of ΔFd entry into parasitized red blood cells (synchronized rings (~7% parasitaemia) and synchronized trophozoites (~20% parasitaemia). Uptake of fluorescently tagged FITC-ΔFd (2.5 μM) was monitored by flow cytometry at 25°C. Panels A and B depict the peptide uptake profiles obtained with rings and trophozoites, respectively. Zero minute profiles correspond to samples not treated with peptide. Figures against percentage gated indicate the number of cells stained above the threshold line. Note (a) the fast uptake and progressive increase in the number of fluorescent signals with time, and (b) faster uptake by trophozoites compared to ring-stage parasitized cells.

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