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Table 1 In-vitro blood stage antiplasmodial activities, resistance and selectivity indices of peptides against different strains of P. falciparum

From: Anti-plasmodial action of de novo-designed, cationic, lysine-branched, amphipathic, helical peptides

Peptides

Peptide Sequence and design

IC50P. falciparum(μM)

Resistance index

HC50URBC μM

3D7

Dd2

INDO

IC50Dd2/ IC503D7

Fm

Ac-GFRKFHKFWA-NH 2

>100

>100

 

-

>100

ΔFm

Ac-GΔFRKΔFHKΔFWA-NH 2

>100

>100

-

-

>100

ΔFd

1.39 ± 0.1

1.6 ± 0.09

1.5 ± 0.075

1.15

>50 ( >35)*

D-Lys-ΔFd**

1.8 ± 0.07

-

-

-

>50 (> 27)

Fd

1.5 ± 0.08

-

-

-

>50 (>33)

(ΔFm) 2

Ac-GΔFRKΔFHKΔFWAAGΔFRKΔFHKΔFWA-NH 2

2.4 ± 0.15

2.5 ± 0.13

-

1.04

>50 (>20)

ΔFq

0.25 ±0.02

-

-

-

2.5 ±0.13 (10)

Prochitinase

EEPHKAASAEGKK

> 40

-

-

-

> 40

E30

NPPDHSAPLGATRPSAPPLPHVVDLPQLGP

> 40

-

-

-

> 40

Insulin

> 40

-

-

-

> 40

Artemisinin

0.015

0.016

0.015

1

 

Chloroquine

0.04

0.16

0.5

4

 
  1. * Hemolytic Selectivity index (HC50URBC/ IC50Pf 3D7) is shown in parenthesis, **: KD refers to Lysine of D configuration. Values of standard deviation given as ± are based on three independent observations.