From: Anti-plasmodial action of de novo-designed, cationic, lysine-branched, amphipathic, helical peptides
Peptides | Peptide Sequence and design | IC50P. falciparum(μM) | Resistance index | HC50URBC μM | ||
---|---|---|---|---|---|---|
3D7 | Dd2 | INDO | IC50Dd2/ IC503D7 | |||
Fm | Ac-GFRKFHKFWA-NH 2 | >100 | >100 | Â | - | >100 |
ΔFm | Ac-GΔFRKΔFHKΔFWA-NH 2 | >100 | >100 | - | - | >100 |
ΔFd |
| 1.39 ± 0.1 | 1.6 ± 0.09 | 1.5 ± 0.075 | 1.15 | >50 ( >35)* |
D-Lys-ΔFd** |
| 1.8 ± 0.07 | - | - | - | >50 (> 27) |
Fd |
| 1.5 ± 0.08 | - | - | - | >50 (>33) |
(ΔFm) 2 | Ac-GΔFRKΔFHKΔFWAAGΔFRKΔFHKΔFWA-NH 2 | 2.4 ± 0.15 | 2.5 ± 0.13 | - | 1.04 | >50 (>20) |
ΔFq |
| 0.25 ±0.02 | - | - | - | 2.5 ±0.13 (10) |
Prochitinase | EEPHKAASAEGKK | > 40 | - | - | - | > 40 |
E30 | NPPDHSAPLGATRPSAPPLPHVVDLPQLGP | > 40 | - | - | - | > 40 |
Insulin |
| > 40 | - | - | - | > 40 |
Artemisinin | 0.015 | 0.016 | 0.015 | 1 | Â | |
Chloroquine | 0.04 | 0.16 | 0.5 | 4 | Â |