Gene | Mutation | Number | Frequency (%) |
---|---|---|---|
pfdhfr | Quadruple mutants | 22 (58) | 38.0 |
Triple mutants 51/59/108 | 9 (58) | 15.5 | |
Triple mutants 59/108/164 | 21 (58) | 36.2 | |
Double mutants 59/108 | 6 (58) | 10.3 | |
pfdhps | Quadruple mutants | 13 (55) | 23.6 |
Triple mutants 436/437/581 | 8 (55) | 14.5 | |
Double mutants 436/437 | 2 (55) | 3.6 | |
Double mutants 436/540 | 1 (55) | 1.8 | |
Double mutants 437/540 | 28 (55) | 50.9 | |
Double mutants 437/581 | 3 (55) | 5.5 |