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Table 2 Panel of multidrug resistant strains including specifc amino acid changes

From: A framework for assessing the risk of resistance for anti-malarials in development

 

drug resistancea

pfcrt b

pfmdr1 c

pfdhfr d

pfdhps e

pfcytb

 

Strain

CHQ

SUL

PYR

CYC

MEF

ATO

72

73

74

75

76

86

184

1034

1042

1246

copy

16

51

59

108

164

436

437

581

613

268

Origin

MR4 number

Ref.

NF54

S

S

S

S

S

S

C

V

M

N

K

N

Y

S

N

D

1

A

N

C

S

I

S

G

A

A

Y

Imported

MRA-100

[25]

D6

S

S

S

S

R

S

C

V

M

N

K

N

Y

S

N

D

1

A

N

C

S

I

A

A

A

A

 

Cloned from Sierra Leone I/CDC

MRA-285

[26]

HB3

S

S

R

S

S

S

C

V

M

N

K

N

Y

S

D

D

1

A

N

C

N

I

S

A

A

A

 

Cloned from Honduras I/CDC

MRA-155

[27]

7 G8

R

S

R

R

  

S

V

M

N

T

N

F

C

D

Y

1

A

I

C

N

I

S

G

A

A

 

Cloned from IMTM 22 (Brazil)

MRA-152

[28]

Dd2

R

R

R

R

R

 

C

V

I

E

T

Y

Y

S

N

D

4

A

I

R

N

I

F

G

A

S

 

Cloned from W2-Mef (Indochina III/CDC)

MRA-150

[29]

V1/S

R

R

R

R

  

C

V

I

E

T

Y

Y

S

N

D

 

A

I

R

N

L

F

G

A

T

 

Cloned from V1 (Vietnam)

MRA-176

[30]

K1

R

R

R

R

  

C

V

I

E

T

Y

Y

S

N

D

1

A

N

R

N

I

S

G

G

A

 

Thailand

MRA-159

[31]

FCB

R

 

S

R

  

C

V

I

E

T

Y

Y

S

N

D

2

V

N

C

T

I

     

Columbia

MRA-309

[32]

TM90C2B

R

 

R

 

R

R

C

V

I

E

T

N

F

S

N

D

          

S

Thailand

N/A

[3]

  1. aS: sensitive, R: resistant, as reported in the literature.
  2. bAllelic information based on references[33–35].
  3. cAllelic information based on references[33, 35–37].
  4. dAllelic information based on references[18, 35, 38].
  5. eAllelic information based on references[20, 39–41].
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Malaria Journal

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