Parameter | Population estimatea | 95% CIb | IIV[%CV]a | 95% CIb |
---|---|---|---|---|
(% RSE)b | (% RSE)b | |||
CLARM/F (L/hr) | 875 (18.7) | 625-1280 | 28.0 (47.6) | 12.0-37.8 |
VARM/F (L) | 2160 (17.4) | 1620-3100 | - | - |
CLDHA/F (L/hr) | 468 (10.2) | 387-588 | 90.4 (39.0) | 40.5-126 |
VDHA/F (L) | 57.1 (20.1) | 41.7-88.8 | - | - |
MTT (hr) | 0.274 (19.4) | 0.174-0.378 | 75.2 (39.6) | 41.4-121 |
DUR (hr) | 0.687 (25.5) | 0.380-1.14 | 151 (24.1) | 90.6-209 |
F | 1 (fixed) | - | 85.5 (24.8) | 53.2-108 |
No. of transit compartments | 6 (fixed) | - | - | - |
σ | 0.166 (6.87) | 0.130-0.221 | 23.1 (51.7) | 8.35-35.2 |
Post-hoc estimates parameters c | Artemether Median (range) | Dihydroartemisinin Median (range) | Â | Â |
AUC60h-∞ (hr × ng/mL) | 111 (16.2-317) | 167 (55.3-437) |  |  |
CMAX (ng/mL) | 32.9 (7.5-82.8) | 45.2 (14.1-114) | Â | Â |
TMAX (hr) | 1.16 (0.65-3.81) | 1.37 (0.82-3.89) | Â | Â |