Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda

Table 3 Summary of parameter estimates for a comparative analysis of different methodologies

Parameter	Approach 1	Approach 2	Approach 3	P-value	P-value	P-value
Parameter	Non compartmental analysis Median [range]	Separate modelling Median [range]	Simultaneous modelling Median [range]	(1 vs 2)	(1 vs 3)	(2 vs 3)
Artemether
CL/F (L/hr)	753 [220-7381]	904 [375-2919]	858 [365-4593]	0.975	0.899	0.972
V/F (L)	1750 [547-11045]	1293 [1279-1301]	2292 [951-4967]	0.002	0.826	0.013
Ka (hr^-1)	-	0.392 [0.137-2.25]	0.878 [0.381-2.17]	-	-	0.008
AUC_60h-LAST (hr × ng/ml)	98.5 [7.24-355]	86.4 [26.5-207]	91.1 [17.4-215]	0.989	0.999	0.983
Dihydroartemisinin
CL/F (L/hr)	381 [167-1364]	534 [220-1116]	496 [214-1199]	0.311	0.459	0.910
V/F (L)	647 [374-4154]	691 [325-1699]	163 [97-200]	0.247	<0.001	<0.001
Ka (hr^-1)	-	0.472 [0.472-0.472]	-	-	-	-
AUC_60h-LAST (hr × ng/ml)	196 [53.2-449]	140 [67.2-340]	150 [62.2-345]	0.304	0.502	0.930

CL/F: elimination clearance, V/F: apparent volume of distribution, Ka: absorption constant and AUC_60h-LAST: total area under the plasma concentration-time curve after the last dose to the last sample time. P-values were presented from an ANOVA test with regression analysis or a student t-test (comparing 2 groups) on log transformed parameter estimates. Non-compartmental analysis (Approach 1), separate modelling (Approach 2) and simultaneous modelling (Approach 3) results.

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