Table 5 A comparison of the dihydroartemisinin pharmacokinetic properties to literature values

Parameter

AUC (hr × ng/mL/ mg dose)

C_MAX (ng/mL/ mg dose)

T_MAX (hr)

T_1/2 (hr)

CL (L/hr/kg)

Pregnant women with uncomplicated malaria

Final model (N = 21)

Median (range)^a

2.11 (0.703-5.44)

0.593 (0.185-1.50)

1.37 (0.82-3.89)

0.10 (0.0150-0.470)

8.06 (10.5)^b

NCA (N = 21)

Median (range)

2.57 (0.698-5.89)

1.09 (0.247-2.01)

1.83 (0.520-4.00)

1.39 (0.690-2.36)

6.91 (2.29-23.1)

NCA in Thai pregnant patients (N = 13)[9]

Median (90% ranges)

4.68 (0.391-7.67)

2.16 (0.944-2.94)

1.00 (0.500-2.00)

1.30 (0.900-8.40)

4.50 (2.80–5.40)

Non-pregnant patients with uncomplicated malaria

NCA in Thai male patients (N = 25)[52]

Mean ± S.D.

7.92 ± 3.40

2.69 ± 1.34

2.00 (1.00-6.00)

1.60 ± 0.400

-

NCA in Thai patients (N = 13)[54]^c

Mean (range)

11.1 (7.04-15.6)

1.41 (0.871-2.12)

4 (2-4)

3.6 (2.4-4.8)

-

Healthy subjects

NCA in Pakistani subjects (N = 12)[42]^d

Median (range)

3.97 (2.57-4.74)

1.60 (0.704-2.56)

1.50 (0.750-3.00)

1.78 (1.34-2.20)

3.70 (3.05-5.27)

NCA in Caucasian subjects (N = 14)[53]

Mean ± S.D.

2.51 ± 1.22

0.982 ± 0.547

1.5 [1-4]

1.5 ± 0.6

-

NCA in Caucasian subjects (N = 8)[50]^e

Mean ± S.D.

2.42 ± 0.682

0.818 ± 0.294

1.6 ± 0.8

0.8 ± 0.3

-