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Table 1 Inhibition of Plasmodium falciparum W2 and recombinant falcipain-2 by Sorindeia juglandifolia extracts

From: Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo

Fractions /Compounds

Solvent system

P. falciparum W2- IC50±SD (μg/ml)

Falcipain-2 IC50±SD (μg/ml)

SJFR1

 

6.24±1.01

8.22±1.09

SJFR2

Hex:EtOAc 10%

11.55±2.45

6.02±3.81

SJFR3

 

>10

>10

SJFR4

 

>10

21.90 ±1.85

SJFR5

Hex:EtOAc 25%

>10

>10

SJFR6

 

>10

>10

SJFR7

 

>10

>10

SJFR8

 

2.76±0.08

>10

SJFR9

 

2.30±0.97

5.42±0.65

SJFR10

Hex:EtOAc 50/50

2.46±0.29

>10

SJFR11

 

>10

>10

SJFR12

 

>10

>10

SJFR13

 

>10

>10

SJFR14

 

>10

>10

SJFR15

Hex:EtOAc 75%

>10

17.31±2.51

SJFR16

 

>10

>10

SJFR17

 

8.47±0.41

1.12±0.16

SJFR18

EtOAc 100%

>10

1.14±0.10

CQ

 

0.05±0.01

 

ART

 

0.007±0.01

 

E64

 

ND

0.049±0.003

2,3,6-trihydroxy benzoic acid (1)

 

16.47±0.47 μM

35.41±22.37μM

2,3,6-trihydroxy methyl benzoate (2)

 

13.04±1.63 μM

6.09±0.87 μM

  1. IC50= Concentration that killed/inhibited 50% of parasites/enzyme relative to negative control. S.D. = standard deviation, the drugs were tested in triplicate. Positive controls were CQ = chloroquine, ART= artemisinin, and E-64 = l-transepoxy-succinyl-leucylamido-(4-guanidino)-butane.