Secondary parameters | Total | Non-pregnant women | Pregnant women | p-value |
---|---|---|---|---|
CMAX (ng/mL) | 158 [40.6-363] | 102 [40.6-235] | 185 [109–363] | 0.021 |
TMAX (hours) | 2.62 [0.887-4.64] | 1.48 [0.887-4.18] | 3.07 [1.65-4.64] | 0.018 |
Half-life (days) | 23.4 [19.1-33.3] | 25.7 [20.9-33.3] | 22.1 [19.1-25.8] | 0.001 |
Day 7 concentration (ng/mL) | 58.3 [16.6-146] | 55.4 [16.6-146] | 60.7 [40.1-103] | 0.671 |
Day 28 concentration (ng/mL) | 15.9 [4.85-38.6] | 15.4 [4.85-38.6] | 16.1 [9.68-26.8] | 0.840 |
AUC0->90 (ng*h/mL) | 40600 [12400–100000] | 38000 [12400–100000] | 42700 [27100–68700] | 0.799 |
AUC48h->90 (ng*h/mL) | 36400 [10600–90300] | 35300 [10600–90300] | 37700 [23500–63200] | 0.887 |