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Table 3 Treatment outcome of AS+AQ versus AL at D28

From: Multicentre study evaluating the non-inferiority of the new paediatric formulation of artesunate/amodiaquine versus artemether/lumefantrine for the management of uncomplicated Plasmodium falciparum malaria in children in Cameroon, Ivory Coast and Senegal

 

Artesunate/Amodiaquine

Artemether/Lumefantrine

p value

Overall treatment outcome

ITT analysis

   

Early treatment failure

00

00

--

Crude parasitological failure at day 28

05/249 (2%)

10/232 (4.3%)

0.14

PCR adjusted failure rate at day 28

04/249 (1.6%)

09/232 (3.8%)

0.12

PCR adjusted ACPR at day 28

242/249 (97.6%)

218/232 (94.8%)

0.11

Difference, % [95%CI] 2.7 [-0.6 - 6.2%]

PP analysis

Early treatment failure

00

00

--

Crude parasitological failure at day 28

05/246 (2%)

10/227 (4.4%)

0.14

PCR adjusted failure rate at day 28

04/246 (1.6%)

09/227 (3.9%)

0.12

PCR adjusted ACPR at day 28

242/246 (98.7%)

218/227 (96.9%)

0.16

Difference, % [95%CI] 1.8 [-0.76 - 4.4]