Figure 5
From: Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii
P. yoelii infected mice that were cured with geldanamycin derivatives exhibit robust immunity against subsequent infection. Infection was induced by injecting ~106 P. yoelii infected mice rbcs. Response of infection was studied in four different groups of mice. (A) Naïve 10 weeks old Swiss mice (control) (▲); mice that were cured of malaria by treatment with (B) 17-AAG or 17-PEG-Alkyn-GA (■) and (C) chloroquine (○) (see Figure 1 for B and C groups of mice). (D) Average parasitemia profile of the three groups. Each group had 6 animals.