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Table 2 PCR success rates and agreement of genotyping outcomes in field samples

From: Rapid diagnostic tests for molecular surveillance of Plasmodium falciparum malaria -assessment of DNA extraction methods and field applicability

 

RDT PCR success rates N = 121 (%; CI 95%)

Filter paper PCR success rates N = 121 (%; CI 95%)

Kappa value

Pfcrt K76T

114 (94.2; 89.9-98.5)

104 (86.0; 79.6-92.3)

0.72

Pfmdr1 N86Y

112 (92.6; 87.8-97.4)

109 (90.1; 84.6-95.5)

0.85

Pfmdr1 Y184F

110 (90.9; 85.7-96.2)

107 (88.4; 82.6-94.3)

0.74

Pfmdr1 D1246Y

113 (93.4; 88.8-97.9)

107 (88.4; 82.6-94.3)

0.77

Pfmdr1 copy number

84 (69.4; 61.0-77.8)

77 (63.6; 54.9-72.4)

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  1. Analyses of single nucleotide polymorphisms and pfmdr1 gene copy numbers associated with anti-malarial drug resistance, from RDT and filter paper extracted DNA collected from 121 RDT positive field samples.