Parenteral antimalarial treatment without exchange transfusion | Parenteral antimalarial treatment with exchange transfusion | |||
---|---|---|---|---|
(n=48) | (n=39) | |||
Quinine monotherapy | Artesunate monotherapy | Quinine + exchange transfusion | Artesunate + exchange transfusion | |
(Group I, n=38) | (Group II, n=10) | (Group III, n=23) | (Group IV, n=16) | |
Demographics | ||||
Age, years note 1 | 39 (33–44) | 42 (33–55) | 48 (38–55) | 52 (44–59) |
Male, female, n (%) note 2 | 25 (66), 13 (34) | 8 (80), 2 (20) | 13 (57), 10 (43) | 10 (63), 6 (37) |
Weight, kg note 2 | 72 (62–81) | 83 (75–86) | 70 (60–90) | 81 (72–87) |
Ethnicity, n (%) note 2 | ||||
Caucasian | 12 (32) | 5 (50) | 14 (60) | 7 (43) |
African | 20 (53) | 5 (50) | 5 (22) | 6 (38) |
Asian | 4 (10) | - | 2 (9) | 2 (13) |
Other/unknown | 2 (5) | - | 2 (9) | 1 (6) |
Continent of acquisition, n (%) note 2 | ||||
Africa, [West-Africa] | 34 (89), [27 (79)] | 10 (100), [7 (70)] | 21 (92), [17 (81)] | 16 (100), [13 (81)] |
Asia | 3 (8) | - | 1 (4) | - |
South-America | 1 (3) | - | 1(4) | - |
Vital signs on admission | ||||
Impaired consciousness (%), [GCS≤11] note 2 | 2 (5), [0 (0)] | 1 (10), [0 (0)] | 5 (22), [3 (60)] | 3 (19), [1 (100)] |
Body temperature, °C note 2 | 38.6 (38.2-40.1) | 39.1 (38.3-39.6) | 38.2 (37.0-39.8) | 38.9 (37.7-39.8) |
Pulse rate, beats per minute note 2 | 100 (90–113) | 96 (90–116) | 101 (91–113) | 105 (100–116) |
Systolic blood pressure, mm Hg note 2 | 120 (113–129) | 118 (111–135) | 113 (95–120) | 125 (100–132) |
Laboratory data on admission | ||||
Parasite load, parasites/μL note 1 | 111,650 (35,750-185,325) | 74,000 (41,400-142,350) | 357,000 (162,000-514,000) | 313,500 (151,950-536,675) |
Schizontaemia, n (%) note 3 | 11 (29) | 2 (20) | 14 (61) | 12 (75) |
Serum creatinine, μmol/L note 4 | 97 (78–114) | 103 (85–124) | 121 (95–159) | 120 (88–163) |
Plasma lactate, mmol/L note 5 | 1.8 (1.5-2.7) | 2.3 (2.0-2.8) | 2.3 (1.8-3.6) | 3.0 (1.9-4.2) |
Severe malaria (WHO 2010), n (%) note 1 | 14 (37) | 3 (30) | 23 (100) | 16 (100) |
Outcome | ||||
Duration hospitalisation, days note 6 | 6 (1–14)& | 5 (4–5) | 9 (3–19) | 9 (6–11) |
Hemodialysis, n (%) note 7 | 0 (0) | 0 (0) | 2 (9) | 3 (19) |
Mechanical ventilation, n (%) note 7 | 0 (0) | 0 (0) | 2 (9) | 2 (13) |
Survival, n (%) note 2 | 38 (100) | 10 (100) | 23 (100) | 15 (94)^ |