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Table 1 General characteristics of patients with imported severe P. falciparum malaria

From: Manual blood exchange transfusion does not significantly contribute to parasite clearance in artesunate-treated individuals with imported severe Plasmodium falciparum malaria

 

Parenteral antimalarial treatment without exchange transfusion

Parenteral antimalarial treatment with exchange transfusion

(n=48)

(n=39)

 

Quinine monotherapy

Artesunate monotherapy

Quinine + exchange transfusion

Artesunate + exchange transfusion

 

(Group I, n=38)

(Group II, n=10)

(Group III, n=23)

(Group IV, n=16)

Demographics

    

 Age, years note 1

39 (33–44)

42 (33–55)

48 (38–55)

52 (44–59)

 Male, female, n (%) note 2

25 (66), 13 (34)

8 (80), 2 (20)

13 (57), 10 (43)

10 (63), 6 (37)

 Weight, kg note 2

72 (62–81)

83 (75–86)

70 (60–90)

81 (72–87)

Ethnicity, n (%) note 2

    

 Caucasian

12 (32)

5 (50)

14 (60)

7 (43)

 African

20 (53)

5 (50)

5 (22)

6 (38)

 Asian

4 (10)

-

2 (9)

2 (13)

 Other/unknown

2 (5)

-

2 (9)

1 (6)

Continent of acquisition, n (%) note 2

    

 Africa, [West-Africa]

34 (89), [27 (79)]

10 (100), [7 (70)]

21 (92), [17 (81)]

16 (100), [13 (81)]

 Asia

3 (8)

-

1 (4)

-

 South-America

1 (3)

-

1(4)

-

Vital signs on admission

    

 Impaired consciousness (%), [GCS≤11] note 2

2 (5), [0 (0)]

1 (10), [0 (0)]

5 (22), [3 (60)]

3 (19), [1 (100)]

 Body temperature, °C note 2

38.6 (38.2-40.1)

39.1 (38.3-39.6)

38.2 (37.0-39.8)

38.9 (37.7-39.8)

 Pulse rate, beats per minute note 2

100 (90–113)

96 (90–116)

101 (91–113)

105 (100–116)

 Systolic blood pressure, mm Hg note 2

120 (113–129)

118 (111–135)

113 (95–120)

125 (100–132)

Laboratory data on admission

    

 Parasite load, parasites/μL note 1

111,650 (35,750-185,325)

74,000 (41,400-142,350)

357,000 (162,000-514,000)

313,500 (151,950-536,675)

 Schizontaemia, n (%) note 3

11 (29)

2 (20)

14 (61)

12 (75)

 Serum creatinine, μmol/L note 4

97 (78–114)

103 (85–124)

121 (95–159)

120 (88–163)

 Plasma lactate, mmol/L note 5

1.8 (1.5-2.7)

2.3 (2.0-2.8)

2.3 (1.8-3.6)

3.0 (1.9-4.2)

Severe malaria (WHO 2010), n (%) note 1

14 (37)

3 (30)

23 (100)

16 (100)

Outcome

    

 Duration hospitalisation, days note 6

6 (1–14)&

5 (4–5)

9 (3–19)

9 (6–11)

 Hemodialysis, n (%) note 7

0 (0)

0 (0)

2 (9)

3 (19)

 Mechanical ventilation, n (%) note 7

0 (0)

0 (0)

2 (9)

2 (13)

 Survival, n (%) note 2

38 (100)

10 (100)

23 (100)

15 (94)^

  1. Data are expressed as median (interquartile range) values or as indicated otherwise. GCS = Glasgow Coma Scale; & Comparison of quinine versus artesunate treatment: p=0.0037.
  2. All notes given in superscript relate to the statistical analysis of all quinine and artesunate monotherapies (n=48) versus all regimens containing exchange transfusion (n=39). note 1 p<0.0001; note 2 p= not significant; note 3 p<0.0005; note 4 p<0.005; note 5 p<0.01; note 6 p<0.001; note 7 p<0.05. ^ One patient succumbed to a suspected pulmonary embolism 8 days after complete parasite clearance.