Figure 2

Vaccine trials with adenovirus vectored CSP used to map CSP epitopes. Three trials using adenovirus-vectored CSP (Ad-C) were performed: trial 1 used Ad-C combined with adenovirus-vectored AMA (Ad-A) given as one immunization (Ad-CA) to six subjects without CHMI; trial 2 used the same dose of Ad-CA given to 18 subjects followed by CHMI four weeks later; trial 3 used Ad-C administered twice 16 weeks apart (to 15 and 14 subjects respectively) followed by CHMI four weeks later. Collection points for PBMC used in this study are shown in boxes. The 17 subjects that were used in this study are identified by trial. Challenge=CHMI.