Figure 3

The distribution across 50 sequential cases of vessel sequestration ( as measured by % of vessels parasitized ) across three sites within the brain are shown as stacked bars ( maximum = 300 represented 100% of vessels parasitized × 3 sites ). Cases are ordered by mean % of vessels parasitized. The dotted horizontal line represents the overall cut-off for “cerebral malaria” (23.3% × 3 sites = 69.9) and demonstrates two outliers as follows: (grey arrow) a case of coma of other cause with anaemia and no evidence of retinopathy whose parietal lobe measures was <23.3% but cerebellum was >23.3%; and (black arrow) a case of severe malaria anaemia whose parietal lobe measure was >23.3% but the child did not meet the clinical case definition of cerebral malaria.