Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica

Malaria Journal

Table 3 Course of parasitaemia after inoculation of compound in different experimental groups

Group	Day 5		Day 7		MST (days)	% survival of animals on day 14
Group	Parasitaemia (%)	Activity (%)	Parasitaemia (%)	Activity (%)	MST (days)	% survival of animals on day 14
G1	0.8 ± 0.02	88.9	3.36 ± 2.1*	88.95	13.3	40
G2	2.15 ± 0.4	70.2	13.2 ± 2*	56.6	11.6	20
G3	2.05 ± 1	71.6	14.9 ± 3.12*	50.99	11.5	20
G4	6.6 ± 2.4	8.4	28.7 ± 4.5^NS	5.6	7
G5	7.2 ± 1.8		30.4 ± 3.6		7.75

Data is given as mean ± SD. Significance of values on day 7 were calculated in comparison to infected control and p-value<0.0005 is marked as *=extremely statistically significant, NS=not significant, MST=Mean Survival Time.

ISSN: 1475-2875