Figure 1
From: The metabolism of primaquine to its active metabolite is dependent on CYP 2D6
CYP2D6-mediated hydroxylation of primaquine. A. Shown is the MSE fragmentation spectrum for primaquine. The (M + 1) charge state of primaquine is highlighted in blue. The major fragment ions of primaquine produced upon MSE fragmentation are also shown along with their corresponding m/z values and structures. B. MSE fragmentation of hydroxylated primaquine. Fragment ions utilized for localization of the hydroxylation to the quinoline core are indicated in red. It should be noted that MSE fragmentation localizes this transformation to the quinoline core, and that the assignment shown is tentative.