A pilot study on quality of artesunate and amodiaquine tablets used in the fishing community of Tema, Ghana

Malaria Journal

Table 1 Percentage of artesunate and amodiaquine anti-malarial tablet per blisterpack manufactured by GPCL and LPL determined by methods in International Pharmacopoeia monograph

Anti-malarial blisterpack identification number	Percentage of artesunate per tablet (%)		Classification based on PhInt acceptable range of 96/98 – 102%	Percentage of amodiaquine per tablet (%)	Classification based on PhInt acceptable range of 90 – 110%
	HPLC	Titrimetric		Spectrophotometry
G1	66.4	92.8	Failed	102.3	Passed
G2	78.1	90.0	Failed	99.4	Passed
G3	85.3	92.2	Failed	104.9	Passed
G4	92.0	92.2	Failed	102.5	Passed
G5	108.9	101.1	Passed	101.5	Passed
G6	84.4	92.2	Failed	105.2	Passed
G7	109.2	92.8	Failed	105.4	Passed
G8	81.12	92.8	Failed	100.4	Passed
G9	99.3	92.2	Failed	100.5	Passed
G10	84.2	94.4	Failed	103.0	Passed
L1	102.1	106.7	Failed	103.1	Passed
L2	114.2	103.9	Failed	103.6	Passed
L3	97.1	100.0	Passed	106.0	Passed
L4	102.6	106.1	Failed	95.2	Passed
L5	93.7	96.7	Passed	5.1	Failed
L6	92.1	93.9	Failed	96.7	Passed
Artstd/Amdstd*	100	100.0	Passed	100*	Passed*

Each anti-malarial blisterpack contains amodiaquine and artesunate tablets. Meaning of abbreviations: G1 to G10 refers to anti-malarial blisterpacks obtained from GPCL, whilst L1 to L6 were obtained from LPL; Artstd refers to artesunate standard ICRS1409 obtained from EMDQ, Strasbourg, France); Amdstd* amodiaquine standard ICRS0209 obtained from EMDQ, Strasbourg, France). PhInt refers to International Pharmacopoea. Note that HPLC was not done for amodiaquine because it is not recommended in the International Pharmacopoea monograph.

ISSN: 1475-2875