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Table 1 Plasmodium falciparum false-negative diagnoses by the HRP2-based test

From: Pfhrp2 and pfhrp3 polymorphisms in Plasmodium falciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic tests

 

Palutop+4®

Microscopy

RT-PCR

HRP2a

HRP3b

Identification

Pan

Pf

Pv

Diagnostic

Parasitaemia

Pf

Pv

  

186/1

+

+

Pf

0.5%

+

212/1

Pf

0.02%

+

+ (B)

55/2

Pf

0.5%

+

+ (B)

56/3

Pf

0.5%

+

+

150/3

Pf

0.001%

+

157/3

c

 

+

+ (B)

183/3

Pf

0.004%

+

+ (C)

  1. Pf = Plasmodium falciparum; Pv = Plasmodium vivax; RT-PCR = real-time polymerase chain reaction.
  2. a − If deletion of pfhrp2 and + if presence of pfhrp2.
  3. (B) Group B, sensitive to PfHRP2, detection, number of type 2 repeats × type 7 repeats between 50 to 100 repeats.
  4. (C) Group C, non sensitive PfHRP2 detection, number of type 2 repeats × type 7 repeats < 43 repeats.
  5. b − If deletion of pfhrp3 and + if presence of pfhrp3.
  6. c Thin and thick blood smears were negative.