From: CRIMALDDI: platform technologies and novel anti-malarial drug targets
 | In vitro pharmacology (HTS Screens) | In vivo pharmacology | Human pharmacology |
---|---|---|---|
Plasmodium falciparum | •  Radioactive (3H-Hypoxanthine) | Human parasite models: | Human challenge |
•  P. falciparum in SCID mouse | |||
•  Colorimetric (pLDH, HRPII) | •  Aotus/Saimiri NHP | ||
Mouse models: | |||
•  Fluorescent (Sybr Green) | •  Plasmodium berghei (including GFP or Luc reporter strains) | ||
•  Transgenic parasite (GFP, Luc reporter strains) | |||
•  Plasmodium vinckei | |||
•  Plasmodium chabaudi | |||
•  Plasmodium yoelii | |||
Plasmodium vivax | Invasion assay | Human parasite models | Â |
Flow cytometry (both at present only medium throughput) | •  Aotus/ Saimiri NHP | ||
Primate models | |||
•  Plasmodium cynomolgi |