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Table 4 Existing in vitro assays for screening compounds against Plasmodium falciparum gametocytes (stage I-V)

From: CRIMALDDI: platform technologies and novel anti-malarial drug targets

In vitro pharmacology

In vitro pharmacology

L/MTS/HTS Screens (using non-transgenic parasites)

MTS/HTS screens (using transgenic parasites)

Microscopic counts of Giemsa smear (gold standard)

Pfs16-GFP transgenic parasites [33].

Flow cytometry of hydroethidine labelled gametocytes [34]

Stage-specific luciferase expression in transgenic parasites [35]

ATP- bioluminescence assay for stage IV-V gametocytes [36, 37]

Three transgenic GFP lines, used for flow cytometry assay [38]

Alamar blue, fluorescent redox indicator [39, 40]

 

Parasite lactate dehydrogenase activity (pLDH) [41]