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Table 5 Existing assays for screening transmission blocking compounds on the sporogonic stages in mosquitoes

From: CRIMALDDI: platform technologies and novel anti-malarial drug targets

Pharmacology

Plasmodium species

L/MTS/HTS Screens

Male exflagellation assay [45]

P. falciparum

Female activation assay (Delves, unpublished)

P. falciparum

Standard membrane feeding assay (SMFA) [46, 47]

P. falciparum

SMFA using PbGFP CON [48]

P. berghei

Anopheles stephensi

P. berghei ookinete development assay [43]

P. berghei (transgenic)

GFP-luc sporozoites in mosquito salivary glands [49]

P. berghei (transgenic)