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Table 4 Main adverse drug reactions in 553 patients treated with atovaquone-proguanil for imported uncomplicated malaria

From: Atovaquone-proguanil in the treatment of imported uncomplicated Plasmodium falciparum malaria: a prospective observational study of 553 cases

At Day 3 (N = 469 (%))

n (%)

Digestive adverse reactions

115 (24.5)

Nausea or vomiting

82 (17.5)

Diarrhoea

16 (3.4)

Abdominal pain

10 (2.1)

Others

7 (1.5)

Cutaneous

10 (2.1)

Headache

18 (7.4)

Myalgia

3 (0.6)

Arthralgia

3 (0.6)

Anxiety

1 (0.2)

Total ADR° at Day 3

150 (32.0)

At Day 7 (N = 364 (%))*

 

Digestive adverse reactions

11 (3.0)

Nausea

3 (0.8)

Diarrhoea

4 (1.1)

Others

4 (1.1)

Cutaneous

7 (1.9)

Headache

7 (1.9)

Total ADR° at Day 7

25 (6.9)

At Day 30 (N = 265 (%))*

 

Digestive adverse reactions

1 (0.4)

Nausea

0

Diarrhoea

1 (0.4)

Cutaneous

1 (0.4)

Headache

0

Total ADR* at Day 30°

2(0.8)

  1. *: Differences between denominators are due to patients lost to follow up.
  2. ADR: Adverse drugs reactions.