In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains

Table 2 In vitro interaction of thapsigargin with OZ277 or semi-synthetic artemisinin derivatives against Plasmodium falciparum K1 and NF54 strains

Thapsigargin combined with:	P. falciparum strains	⁺(∑FIC) ± Standard error at different ratio of drug combinations
		1:3		1:1		3:1
		∑FIC₅₀	∑FIC₉₀	∑FIC₅₀	∑FIC₉₀	∑FIC₅₀	∑FIC₉₀	mean ∑FIC₅₀*	mean ∑FIC₉₀*
OZ277	K1	1.0 ± 0.0	1.0 ± 0.1	1.1 ± 0.0	1.1 ± 0.1	1.4 ± 0.1	1.4 ± 0.1	1.2	1.2
	NF54	1.0 ± 0.1	1.0 ± 0.0	1.2 ± 0.1	0.9 ± 0.0	1.1 ± 0.1	0.9 ± 0.0	1.1	0.9
Artemether	K1	1.2 ± 0.2	1.1 ± 0.0	1.1 ± 0.0	1.0 ± 0.1	1.1 ± 0.1	0.9 ± 0.1	1.1	1.0
	NF54	1.1 ± 0.1	1.0 ± 0.1	0.9 ± 0.1	0.9 ± 0.0	1.2 ± 0.1	1.0 ± 0.0	1.1	1.0
Artesunate	K1	1.2 ± 0.0	1.2 ± 0.0	1.2 ± 0.1	1.2 ± 0.2	1.3 ± 0.0	1.1 ± 0.1	1.2	1.2
	NF54	1.1 ± 0.0	1.0 ± 0.0	1.1 ± 0.1	1.0 ± 0.1	1.0 ± 0.0	1.0 ± 0.1	1.1	1.0

⁺ Data was obtained from three independent experiments. * m∑FICs was used to classify the overall nature of the interaction which appears to be additive in this study.

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