Table 3 Distribution of gene variants in children from the group of uncomplicated malaria and that of asymptomatic children
Gene Variant | Unc malar (n=179) | Asym (n=138 ) | OR (95%CI) | P value | |
|---|---|---|---|---|---|
IL10RA ss491228441 T/G | Genotypes | ||||
TT | 176 (0.98) | 125 (0.91) | |||
TG | 3 (0.02) | 13 (0.09) | |||
GG | 0 (0) | 0 (0) | |||
Allele | |||||
T | 355 (0.99) | 263 (0.95) | Reference | ||
G | 3 (0.01) | 13 (0.05) | 0.16 (0.04-0.61) | 0.007 | |
Dominant | |||||
TT | 176 (0.98) | 125 (0.91) | 6.35 (1.68-23.9) | 0.006 | |
TG+GG | 3 (0.02) | 13 (0.09) | |||
Recessive | |||||
GG | 0 (0) | 0 (0) | NA | ||
TT+TG | 179 (1.0) | 138 (1.0) | |||
STAT6 rs3024944 G/C | Genotypes | ||||
GG | 145 (0.81) | 106 (0.77) | |||
GC | 30 (0.17) | 17 (0.12) | |||
CC | 4 (0.02) | 15 (0.11) | |||
Allele | |||||
G | 320 (0.89) | 229 (0.82) | Reference | ||
C | 38 (0.11) | 47 (0.18) | 0.57 (0.35-0.91) | 0.019 | |
Dominant | |||||
GG | 145 (0.81) | 106 (0.77) | NS | ||
GC+CC | 34 (0.19) | 32 (0.23) | |||
Recessive | |||||
CC | 4 (0.02) | 15 (0.11) | 0.17 (0.05-0.55) | 0.003 | |
GG+GC | 175 (0.98) | 123 (0.89) | |||