Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections

Table 5 Estimated Plasmodium falciparum genotype frequencies, and their values at the extremes of their 95% credible intervals (in parentheses), in the five Ugandan study sites

Frequencies were estimated using the model, the prevalence data and the mean MOI reported by Francis et al. at each site [31]. The genotypes are defined by the amino acid residues they encode at codons 51, 59, 108 in Pfdhfr, and 437 and 540 in Pfdhps. The amino acid residues are given by their one letter amino acid code. Residues encoded by resistance markers are underlined. All genotypes that are theoretically compatible with the data were considered by the model, however, only those with a frequency greater than 0.03 at one or more sites are reported.

ISSN: 1475-2875