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Table 1 Histopathological changes and grading schemes used to evaluate liver tissues

From: Liver changes in severe Plasmodium falciparum malaria: histopathology, apoptosis and nuclear factor kappa B expression

Histopathologic changes

Histopathologic grading

0

1

2

3

Fatty change

No fatty change

< 10%

10-50%

> 50%

Kupffer cells/HPF

< 20/HPF

20-35/HPF

36-50/HPF

> 50/HPF

Portal tract inflammation

< 5% of portal tract area

5-15% of portal tract area

16-30% of portal tract area

> 30% of portal tract area

Bile duct proliferation

No proliferation

Mild proliferation

Moderate proliferation

Severe proliferation

Sinusoid congestion

No congestion

Mild congestion

Moderate congestion

Severe congestion

Haemozoin deposition

No deposition

Mild deposition

Moderate deposition

Severe deposition

  1. HPF = high power field (magnification 400x).