Table 1 Definitions
Measure | Definition | Population | Analysis |
|---|---|---|---|
Parasite clearance | Patients’ conversion from a positive to a negative parasite slide within 7 days post-treatment start (independent of whether it was sustained throughout the entire duration of follow-up or there was a recurrent episode). | All studies, whether comparative or not (n = 15,017) | Observed median time of parasite clearance |
Delayed parasite clearance | - Parasitaemia positive on | Prevalence, risks by multivariate analysis | |
o Day 2 | |||
o Day 3 | |||
Parasite clearance failure | - Day 2 parasitaemia > pre-treatment parasitaemia | ||
- Day 3 parasitaemia >25% pre-treatment parasitaemia | |||
- Consecutive positive slides up to Day 7 | |||
Parasite reduction ratio | Relative difference (referent: parasite before treatment) | ASAQ groups (n = 2,355) where parasite densities were measured once daily from Days 0 to 3 and Day 7 | Reduction rate |
Predicted time of parasite clearance | Modelling the time of parasite clearance | Predict the time of parasite clearance using the parasitaemia before treatment and the proportions of positive patients |