Skip to main content

Table 4 Association between levels of antibodies (two-fold increment) at 10.5 months of age and the incidence of malaria up to 24 months of age

From: Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique

  

10.5-24 months

Antigens

Antibodies

Crude

Adjusted

  

IRR1

95% CI

P value2

IRR

95% CI

P value

MSP-119

IgG

1.26

1.03; 1.55

0.0269

1.15

0.94; 1.40

0.1710

IgG1

1.23

1.01; 1.49

0.0385

1.13

0.94; 1.36

0.2081

IgG2

0.82

0.45; 1.49

0.5226

0.76

0.45; 1.27

0.2968

IgG3

1.19

0.77; 1.82

0.4235

0.94

0.63; 1.39

0.7423

IgG4

1.35

0.75; 2.42

0.3096

1.27

0.69; 2.33

0.4361

IgM

0.98

0.65; 1.49

0.9419

1.01

0.70; 1.45

0.9654

AMA-1

IgG

1.86

1.37; 2.53

< 0.0001

1.31

1.00; 1.72

0.0533

IgG1

1.68

1.26; 2.25

0.0002

1.21

0.94; 1.57

0.1366

IgG2

1.12

0.57; 2.23

0.7446

0.98

0.57; 1.67

0.9354

IgG3

1.06

0.71; 1.59

0.7446

0.98

0.71; 1.33

0.8743

IgG4

2.78

1.13; 6.81

0.0261

1.85

0.83; 4.14

0.1360

IgM

1.65

0.94; 2.87

0.0811

2.08

1.26; 3.45

0.0037

EBA-175

IgG

0.73

0.50; 1.09

0.1235

0.67

0.47; 0.94

0.0178

IgG1

0.75

0.50; 1.13

0.1735

0.75

0.54; 1.04

0.0874

IgG2

0.74

0.50; 1.09

0.1124

0.69

0.50; 0.90

0.0239

IgG3

0.90

0.58; 1.40

0.6580

0.80

0.55; 1.17

0.2469

IgG4

0.89

0.56; 1.41

0.6152

0.75

0.49; 1.14

0.1741

IgM

1.12

0.72; 1.74

0.6113

1.48

1.02; 2.14

0.0358

VSA

IgG

1.02

0.76; 1.36

0.8827

0.92

0.68; 1.24

0.5864

  1. Analysis done by negative binomial regression models adjusted by treatment, season, neighbourhood, current infection, previous infection, maternal infection, congenital infection, placental inflammation, insecticide-treated bed net use, and indoor residual spraying.
  2. 1Incidence rate ratio.
  3. 2Negative binomial regression model using likelihood ratio test.