Population pharmacokinetics of mefloquine, administered as a fixed-dose combination of artesunate-mefloquine in Indian patients for the treatment of acute uncomplicated Plasmodium falciparum malaria

Table 3 Pharmacokinetics parameters of mefloquine in the present work and in previous studies

Parameter	Gutmanet al.[19]	Charleset al.[20]	Ashleyet al.[21]	Krudsoodet al.[18]	Current study
Country of study	Peru	Australia	Thailand	Thai-Burmese border	India
context	uncomplicated falciparum malaria	prophylaxis	uncomplicated falciparum malaria	uncomplicated falciparum malaria	uncomplicated falciparum malaria
Age (yr): Mean (range)
	36	26	19 (Median)	27.8	28
	18 - 61	18 - 55	2 - 55	16 - 50	18 -45
BW (kg)
Mean	NA	82	44.5 (Median)	51	53.3
Range	NA	53 -135	10 - 63	40 - 65	40 - 70
CL/F	0.017 L/h/kg	2.09 L/h	1.33 L/h	0.024 L/h/kg	1.13 L/h
CL/F	0.017 L/h/kg	2.09 L/h	1.33 L/h	0.024 L/h/kg	0.022 L/h/kg
V/F	8.57 L/kg	1011 L	488 L	NA	615 L
V/F	8.57 L/kg	1011 L	488 L	NA	11.9 L/kg
T_1/2	14.5 days	14 days	10.5 days	13.4 days	21.6 days

ISSN: 1475-2875