Table 1 Inhibitory activities of lumefantrine, piperaquine, pyronaridine and atovaquone alone and in combination with atorvastatin against 13 strains of Plasmodium falciparum
From: In vitro interaction of lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum
Anti-malarial drugs | Lumefantrine | Piperaquine | Pyronaridine | Atovaquone | ||||
|---|---|---|---|---|---|---|---|---|
IC50mean (nM) | P-value | IC50mean (nM) | P-value | IC50mean (nM) | P-value | IC50mean (μM) | P-value | |
Alone | 31.9 ± 15.1 | 61.1 ± 15.5 | 30.3 ± 9.6 | 3.79 ± 2.0 | ||||
+ 0.12 μM Atorvastatin | 28.1 ± 15.1 | 0.0068 | 59.5 ± 19.7 | NS | 28.9 ± 9.2 | NS | 3.35 ± 1.5 | NS |
+ 0.25 μM Atorvastatin | 26.3 ± 12.4 | 0.0019 | 61.7 ± 18.7 | NS | 29.1 ± 10.1 | NS | 3.35 ± 1.6 | NS |
+ 0.5 μM Atorvastatin | 24.6 ± 11.7 | 0.0019 | 52.5 ± 17.5 | 0.0146 | 28.4 ± 10.2 | NS | 3.23 ± 1.3 | NS |
+ 1 μM Atorvastatin | 20.5 ± 11.0 | 0.0009 | 51.2 ± 19.2 | 0.0244 | 26.9 ± 10.0 | NS | 2.93 ± 1.3 | NS |