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Figure 6 | Malaria Journal

Figure 6

From: Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum

Figure 6

Two-dimensional Principal Component Analysis similarity scatterplot defining the chemical space of the 178 hits. Data points represent compounds encoded as 1024-bit Dotmatics FPCA fingerprints on the first two principal component dimensions. The points are colour-coded by LEI, where greener indicates a higher (better) LEI value. For comparison purposes, 12 commercial anti-malarial agents (grey squares) were included in this plot and their respective abbreviation along with their structure is displayed. Points with circular shape indicate compounds that were eventually removed from the next stage.

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