Skip to main content

Table 4 Diagnostic accuracy of Pf HRP2 versus Pf -pLDH by age group and by season

From: Accuracy of Pf HRP2 versus Pf-pLDH antigen detection by malaria rapid diagnostic tests in hospitalized children in a seasonal hyperendemic malaria transmission area in Burkina Faso

 

Nr

Slide Pf pos (%)

Pf HRP2

Pf-pLDH

 

SE

Sp

PPV

NPV

SE

Sp

PPV

NPV

(95% C.I.)

(95% C.I.)

(95% C.I.)

(95% C.I.)

(95% C.I.)

(95% C.I.)

(95% C.I.)

(95% C.I.)

Age (m)

          

1 – 11

194

39.7

100.0

70.9

69.4

100.0

98.7

94.0

91.6

99.1

   

94.7-100.0

67.4-70.9

65.7-69.4

95.1-100.0

93.5-99.9

90.6-94.8

86.8-92.7

95.5-100.0

12 – 59

401

64.1

100.0

39.6

74.7

100.0

100.0

86.8

93.1

100.0

   

98.3-100.0

36.6-39.6

73.5-74.7

92.5-100.0

98.4-100.0

84.0-86.8

91.6-93.1

96.7-100.0

≥ 60

99

42.4

100.0

68.4

70.0

100.0

100.0

94.7

93.3

100.0

   

91.1-100.0

61.9-68.4

63.8-70.0

90.4-100.0

92.3-100.0

89.1-94.7

86.2-93.3

94.0-100.0

Season

          

Rainy

398

76.4

100.0

35.1

83.3

100.0

99.7

85.1

95.6

98.8

   

98.7-100.0

30.8-35.1

82.2-83.3

87.6-100.0

98.2-100.0

80.5-86.1

94.2-95.9

93.4-99.9

Post-rainy

151

36.4

100.0

46.9

51.9

100.0

100.0

87.5

82.1

100.0

   

92.7-100.0

42.7-46.9

48.1-51.9

91.1-100.0

93.2-100.0

83.6-87.5

76.5-82.1

95.5-100.0

Hot dry

145

11.7

100.0

78.9

38.6

100.0

100.0

97.7

85.0

100.0

   

78.7-100.0

76.1-78.9

30.4-38.6

96.4-100.0

81.7-100.0

95.2-97.7

69.5-85.0

97.5-100.0

  1. Pf = P. falciparum, Pf HRP2 = P. falciparum Histidine-rich protein-2, Pf-pLDH = P. falciparum- specific parasite lactate dehydrogenase, pos = positive, SE = sensitivity, Sp = specificity, PPV = positive predictive value, NPV = negative predictive value.