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Figure 4 | Malaria Journal

Figure 4

From: Effects of the vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor SU5416 on in vitro cultures of Plasmodium falciparum

Figure 4

Specific or unspecific inhibition of VEGFR-2, by addition of SU5416 or genistein to cultures of Plasmodium falciparum , reduces phosphorylation of several tyrosine kinases in red blood cells. This result is not replicated by addition of anti-VEGFR-1 or bevacizumab. Median intensity of bands, obtained by staining western blots of red blood cells after culture, for several phosphorylated tyrosine kinases, with molecular weights of 30, 55, 60, 70, and 90 kDa respectively. Cultures were performed in duplicate with the addition of increasing concentrations of SU5416, genistein, anti-VEGFR-1, or bevacizumab. SU5416 (A) and genistein (B) inhibited several of the tested tyrosine kinases in a dose dependent manner. This was not the case for anti-VEGFR-1 (C) or bevacizumab (D).

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