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Table 1 Ex vivo susceptibility of Plasmodium falciparum isolates against chloroquine, monodeshethylamodiaquine, quinine, lumefantrine and dihydroartemisinin

From: Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change

 

Culture success rate % (n/N)

IC50 mean (nM) [95% CI]

Range (nM)

Resistant isolates (%)

Minimum

Maximum

Chloroquine

86.8 (382/440)

69.2 [60.6 – 79.1]

8.3

595.9

161 (42.1)

Quinine

86.8 (382/440)

162.1 [148.3 – 177.3]

10.2

950.3

4 (1.0)

Monodesethylamodiaquine

85.7 (377/440)

19.3 [18.0 – 20.6]

0.8

595.9

24 (6.4)

Lumefantrine

86.8 (382/440)

25.1 [22.4 – 28.2]

0.8

166.1

NA

Piperaquine

79.3 (349/440)

6.3 [5.9 – 6.8]

0.8

375.2

NA

Dihydroartemisinin

86.5 (381/440)

0.8 [0.8 – 0.9]

0.1

38.8

NA

  1. Resistance threshold defined for chloroquine at 100 nM, quinine at 800 nM and monodeshethylamodiaquine at 60 nM; NA: Non applicable as the threshold is not defined yet.