Ex vivo anti-malarial drugs sensitivity profile of Plasmodium falciparum field isolates from Burkina Faso five years after the national policy change

Table 2 Ex vivo IC ₅₀ of Plasmodium falciparum isolates against monodeshethylamodiaquine, quinine, lumefantrine, piperaquine and dihydroartemisinin by chloroquine susceptibility

Drug	Chloroquine-resistant isolates (n = 161)	Chloroquine-sensitive isolates (n = 221)	P value
Chloroquine	289.8 [269.2 – 312.0)]	24.4 (22.8 – 26.1)	0.0001
Monodesethylamodiaquine	33.8 [31.4 – 36.4]	12.8 [12.0 – 13.6]	0.0001
Quinine	249.7 [223.3 – 279.1]	120.4 [107.2 – 135.2]	0.0001
Lumefantrine	21.9 [18.8 – 25.5]	27.8 [23.5 – 32.8]	0.0006
Piperaquine	6.5 [5.7 – 7.3]	6.1 [5.6 – 6.7]	0.382
Dihydroartemisinin	0.7 [0.6 – 0.8]	0.9 [0.8 – 1.0]	0.001

ISSN: 1475-2875