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Table 4 HR and hQT stratified according to severe malaria-defining sings and symptoms and selected additional parameters on day 0

From: Disease-associated QT-shortage versus quinine associated QT-prolongation: age dependent ECG-effects in Ghanaian children with severe malaria

Signs day 0

No. (%)

HR (per min)

hQT (ms, Wernicke)

With sign

Without sign

P value

With sign

Without sign

P value

Clinical signs

Coma

48/177 (27)

144 (±25)

142 (±28)

0.688

381 (±34)

381 (±30)

0.996

Prostration

155/177 (88)

142 (±28)

142 (±23)

0.983

379 (±34)

396 (±28)

0.025

Multiple convulsions (per 24 h)

92/177 (52)

141 (±26)

143 (±28)

0.617

381 (±37)

381 (±30)

0.967

Respiratory Distress

22/177 (12)

152 (±40)

141 (±25)

0.069

360 (±40)

384 (±31)

0.002

Jaundice

53/177 (30)

137 (±23)

144 (±28)

0.086

391 (±34)

377 (±30)

0.010

Haemoglubinuria

36/175 (21)

136 (±25)

144 (±28)

0.147

391 (±34)

379 (±32)

0.046

Circularly collapse

14/178 (8)

147 (±21)

143 (±25)

0.506

384 (±34)

381 (±33)

0.700

Laboratory signs

Hypoglycaemia

10/177 (5)

140 (±51)

142 (±25)

0.805

375 (±20)

381 (±34)

0.595

Metabolic acidosis (BE < −8)

55/171 (32)

152 (±32)

137 (±23)

<0.001

367 (±32)

388 (±32)

<0.001

Severe anaemia (Hb < 5 g/dl)

41/164 (25)

149 (±35)

140 (±24)

0.052

383 (±33)

373 (±33)

0.089

Hyperparasitaemia

53/177 (30)

151 (±21)

138 (±28)

0.002

374 (±29)

384 (±35)

0.086

Hyperlactataemia (>5 mmol/l)

63/172 (37)

155 (±28)

134 (±24)

<0.001

367 (±38)

389 (±27)

<0.001

Renal impairment (creatinine >3 mg/dl)

3/163 (2)

106 (±31)

142 (±24)

0.016

411 (±34)

382 (±32)

0.128

Additional parameters

Male gender

102/177 (58)

141 (±30)

144 (±22)

0.548

379 (±33)

384 (±33)

0.247

Capillary refill time ≥ 3 s

17/177 (10)

135 (±42)

143 (±25)

0.255

382 (±34)

380 (±33)

0.863

  1. Values are means (±SD) if not indicated otherwise, unpaired t-test.