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Table 1 In vitro sensitivity of Plasmodium falciparum isolates (represented by IC 50 values) to chloroquine (CQ), quinine (QN), mefloquine (MQ), and artesunate (AS) and their sensitivity classification

From: Four years’ monitoring of in vitro sensitivity and candidate molecular markers of resistance of Plasmodium falciparum to artesunate-mefloquine combination in the Thai-Myanmar border

Drug

Sensitivity classification

% (n)

IC50, nM

AS

All

100 (119)

2.0 (1.7–2.3)

Sensitive (IC50 ≤2.3 nM)

58.0 (69)

1.4 (1.8–2.8)

Declined sensitivity (IC50 >2.3 nM)

42.0 (50)

3.4 (3.1–3.7)

MQ

All

100 (119)

30.1 (21.8–33.3)

Sensitive

42.0 (50)

15.2 (12.8–17.6)

Resistant

58.0 (69)

54.1 (46.8–61.4)

CQ

All

100 (119)

72.3 (67.3–77.3)

Sensitive

0.8 (1)

9.6

Moderate resistant

73.1 (87)

66.6 (63.5–69.7)

Highly resistant

26.1 (31)

131.6 (118.9–144.4)

QN

All

100 (119)

231.7 (192.2–271.2)

Sensitive

86.6 (103)

222.6 (195.5–249.8)

Resistant

13.4 (16)

648.9 (621.2–676.5)

  1. Data presented as median (95% CI) and percentage (number).